Abcam, ab222911, Anti-SH3PX1/SNX9 antibody

Size: 50µL
Rabbit Polyclonal SH3PX1/SNX9 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SNX9 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SNX9 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9Y5X1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SH3PX1 also known as SNX9 is a protein with a mass of approximately 69 kDa. This protein contains an SH3 domain which enables it to bind to other proteins and participate in intracellular signaling pathways. SNX9 is widely expressed in various tissues including the brain and liver indicating a broad functional role in cellular processes. The expression of SNX9 in different cell types suggests its involvement in multiple cellular processes including membrane trafficking and cytoskeletal dynamics.
Biological function summary
Functions of SNX9 extend to cellular endocytosis and membrane remodeling. It is part of the retromer complex which plays a role in sorting endosomal proteins back to the trans-Golgi network or plasma membrane. SNX9 facilitates the curvature of cellular membranes aiding the process of clathrin-mediated endocytosis. This protein's ability to bind with both phospholipids and cytoskeletal components highlights its importance in maintaining cellular architecture and facilitating signal transduction.
Pathways
SNX9 integrates into the endocytic and signaling pathways. Its involvement in clathrin-mediated endocytosis and interactions with proteins like dynamin and WASP indicate its key role in vesicle formation and intracellular transport. SNX9 also participates within the Wnt signaling pathway functioning alongside proteins like LRP6 and GSK3 to mediate signal transduction processes that regulate cell fate determination. These pathways underline SNX9's significance in processes controlling cellular growth and differentiation.
Alterations in SNX9 expression or function have associations with neurological disorders and cancer. SNX9 interactions with proteins like Cdc42 and cortactin highlight its relevance in brain development and its implications in schizophrenia. Abnormalities in SNX9-mediated endocytosis can disrupt cellular signaling leading to oncogenic transformation and contributing to the progression of cancers such as breast cancer. Understanding SNX9's role in these conditions may offer insights into potential therapeutic targets.