Abcam, ab223479, Anti-RALB antibody

Size: 50µL
Rabbit Polyclonal RALB antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Ras-related protein Ral-B.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Ras-related protein Ral-B.P11234

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RALB also known as Ras-related protein Ral-B is a member of the small GTPase superfamily with a mass of about 23 kDa. It functions mechanically as a molecular switch cycling between an active GTP-bound state and an inactive GDP-bound state. Its principally known roles involve endocytosis exocytosis and regulation of cell proliferation. RALB expresses in multiple tissues with higher levels observed in the brain lungs and pancreas.
Biological function summary
RALB plays important roles in membrane trafficking and cellular processes. It forms complexes with exocyst components facilitating the tethering and fusion of vesicles with target membranes. RALB interacts with various effector proteins such as Sec5 and RalBP1 to modulate cytoskeletal dynamics and vesicle trafficking. Through these activities RALB influences cell migration cell division and even tumorigenesis.
Pathways
RALB contributes significantly to the regulation of the Ras signaling pathway and the exocyst pathway. It interacts closely with the Ras family of proteins and can be activated by signals upstream in these pathways. In particular RALB's role within the exocyst pathway facilitates the targeting and delivery of secretory vesicles impacting processes like synaptic transmission and immune response. RALB also links with proteins like RALA and RAS coordinating diverse cellular activities.
RALB links to cancer progression and invasion due to its role in cell migration and proliferation. Its activity relates to conditions like pancreatic and bladder cancer where it can affect tumor growth and metastasis. Studies have shown that RALB activity influences autophagy and apoptotic pathways interacting with proteins such as mTOR and p53 which are key players in cancer development.