Abcam, ab224044, Anti-CYC1 antibody

Size: 100µL
Rabbit Polyclonal CYC1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CYC1 aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CYC1 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P08574

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYC1 also known as Cytochrome c1 is a subunit of the cytochrome bc1 complex or complex III located in the inner mitochondrial membrane. It has a molecular mass of approximately 30 kDa. CYC1 is expressed in various tissues with high energy demands such as heart skeletal muscle and brain. As part of complex III CYC1 plays an important role in the electron transport chain facilitating the transfer of electrons from ubiquinol to cytochrome c contributing to the generation of a proton gradient across the mitochondrial membrane.
Biological function summary
The electron transport functionality of CYC1 is essential for ATP production through oxidative phosphorylation. CYC1 is a component of the cytochrome bc1 complex which includes other subunits such as Cytochrome b and the Rieske iron-sulfur protein. This interaction allows CYC1 to transfer electrons within the complex driving the conversion of biochemical energy stored in reduced substrates into ATP.
Pathways
CYC1 takes part in the mitochondrial oxidative phosphorylation pathway a critical process for cellular respiration. It also interacts within electron transfer pathways alongside related proteins such as Cytochrome c and Complex IV. Their coordinated actions ensure efficient energy production and maintain the mitochondrial function. Its proper function within these pathways is necessary for maintaining metabolic balance in cells.
Defects in CYC1 can connect to metabolic anomalies like mitochondrial diseases and cardiomyopathies. Mutations affecting the CYC1 subunit may impair oxidative phosphorylation leading to energy deficits in cells. Additionally disruptions in CYC1 functionality have been linked to disorders involving Cytochrome b another component of the cytochrome bc1 complex contributing to the pathogenesis of various mitochondrial myopathies.