Abcam, ab224077, Anti-C2orf40/ECRG4 antibody

Size: 100µL
Rabbit Polyclonal C2orf40/ECRG4 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ECRG4 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ECRG4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H1Z8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C2orf40 also known as ECRG4 (esophageal cancer related gene 4) is a protein with a molecular mass of approximately 14 kDa. It is expressed widely in human tissues including the brain testis and liver. ECRG4 functions as a membrane protein and plays a role in various cellular processes. Researchers often refer to it when studying its expression in normal and cancerous tissues due to its involvement in cell growth and regulation.
Biological function summary
ECRG4 participates in multiple cellular functions and takes part in neurogenesis and inflammation processes. The protein is not known to be part of a specific multiprotein complex. Its role extends to modulating cell cycle arrest and apoptosis indicating it has a regulatory function within the cell. Studies show its expression might influence tumor suppression and regeneration in tissue injury.
Pathways
ECRG4 plays a role in both the Wnt and NF-kB signaling pathways. These pathways are essential for cell proliferation and inflammation respectively. In the Wnt pathway ECRG4 can interact with proteins like beta-catenin to influence cell fate decisions. In the NF-kB signaling pathway this protein might modulate the transcription of genes that are part of immune responses and survival mechanisms.
ECRG4 has been linked to esophageal cancer and Alzheimer's disease. In cancer ECRG4 expression levels can impact tumor growth and might correlate with disease prognosis. When related to Alzheimer's this protein has connections with amyloid precursor protein which plays a significant role in the disease's pathology. ECRG4's varied roles in these disorders make it a focus of interest for therapeutic research.