Abcam, ab224095, Anti-Orai3 antibody

Size: 100µL
Rabbit Polyclonal ORAI3 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ORAI3 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ORAI3 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.Q9BRQ5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Orai3 is a protein known as a part of the calcium release-activated calcium (CRAC) channel family. It is also referred to as Orai calendar in certain contexts. This protein serves as a critical component in the highly selective process of calcium ion entry across the plasma membrane. Orai3 has a mass of approximately 33 kDa. It is expressed predominantly in tissues like the pancreas lung and immune system which often require tight regulation of calcium homeostasis for their proper function.
Biological function summary
Orai3 plays an essential role in cellular calcium signaling important for various cell functions such as gene expression secretion and metabolism. It often combines with other subunits of the Orai family like Orai1 to form functional calcium channels. Orai3 may form different channel complexes affecting the amplitude and kinetics of calcium entry. Its presence ensures that cells can adapt to specific physiological contexts where calcium influx is required.
Pathways
Orai3 is a significant part of the store-operated calcium entry (SOCE) pathway which activates when intracellular calcium stores get depleted. This pathway is important for maintaining cellular calcium and proteins like STIM1 work closely with Orai3 to initiate calcium influx. The interplay between STIM1 and Orai3 ensures proper signal transduction essential for processes like T-cell activation and other immune responses.
Orai3 has implications in certain cancers and cardiovascular diseases. In some cancer types like breast cancer overexpression of Orai3 contributes to cell proliferation and survival which can lead to tumor progression. Similarly in cardiovascular diseases altered function or expression of Orai3 may impact calcium regulation leading to issues such as hypertension. Its association with STIM1 in these disorders highlights the cooperative role they play in maintaining cellular health emphasizing the importance of regulated calcium influx in normal and disease states.