Abcam, ab224142, Anti-Atrophin 1 antibody

Size: 100µL
Rabbit Polyclonal Atrophin 1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATN1 aa 500-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ATN1 aa 500-700. The exact immunogen used to generate this antibody is proprietary information.P54259

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Atrophin 1 also known by names like Atropin is a protein involved in transcriptional regulation. It has a mass of approximately 230 kDa. This protein exhibits wide expression in the body with detectable levels in neuronal tissues and the brain. Atrophin 1 functions to interact with other proteins influencing gene expression through modulation of chromatin structure.
Biological function summary
Atrophin 1 serves essential roles in cellular processes by acting as a transcriptional co-repressor. It participates in developmental functions and neural growth. Atrophin 1 becomes part of protein complexes that alter gene expression by modifying chromatin states. This role connects it with several developmental regulatory networks.
Pathways
Atrophin 1 engages in signaling networks especially those relating to neural development and apoptosis. It interacts within the Notch signaling pathway a significant regulator of cell fate decisions. Atrophin 1 also interfaces with proteins like RBP-Jk facilitating transcriptional output from Notch signaling.
Atrophin 1 is tightly associated with Dentatorubral-pallidoluysian atrophy (DRPLA) a neurodegenerative disorder. In DRPLA Atrophin 1 undergoes polyglutamine expansion resulting in protein misfolding and aggregation. The abnormally expanded Atrophin 1 affects neural integrity. Connections with other proteins like huntingtin which also involves polyglutamine expansions hint at shared disease mechanisms and potential therapeutic targets.