Abcam, ab224234, Anti-FAM198B antibody

Size: 100µL
Rabbit Polyclonal FAM198B antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GASK1B aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GASK1B aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q6UWH4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FAM198B protein also known as Family with Sequence Similarity 198 Member B is an interesting biological target with yet undisclosed precise functions. It has a mass of approximately 64 kDa. FAM198B is expressed in various types of tissue notably in brain and skeletal muscle tissues. While the protein's exact mechanical role remains incompletely characterized initial research highlights its potential regulatory activities in cellular processes due to its expression patterns.
Biological function summary
FAM198B might influence cellular pathways involving muscle function and neurological systems. Although it is not currently known to be part of a protein complex its expression suggests involvement in cellular growth or differentiation processes. Its behaviors upon overexpression or suppression in studies suggest it may impact cell cycle regulation potentially by interacting with other regulatory proteins or genetic regions.
Pathways
FAM198B may intersect with the MAPK signaling pathway known for its role in regulating cellular activities such as proliferation differentiation and response to external stress signals. It may also show a link to the PI3K-Akt signaling pathway impacting cell survival and metabolism. These pathways involve a multitude of proteins including kinases and phosphatases pointing towards a process where FAM198B could modulate certain steps within these pathways either directly or through secondary messengers.
FAM198B has potential associations with neurodegenerative diseases and muscle wasting disorders. Its expression profile in brain and muscle tissues connects it to clinical conditions where these tissues are affected such as Alzheimer's disease or muscular dystrophies. Studies are also probing its interaction with proteins like Tau linked to neurodegeneration which could further elucidate its role in these diseases. Understanding FAM198B’s exact impacts offers new perspectives on therapeutic strategies targeting these disorders.