Abcam, ab224725, Anti-USP6 antibody

Size: 50µL
Rabbit Polyclonal USP6 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USP6 aa 1100-1400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human USP6 aa 1100-1400. The exact immunogen used to generate this antibody is proprietary information.P35125

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The USP6 protein also known as Tre-2 or Ubiquitin-Specific Peptidase 6 serves as a deubiquitinating enzyme. It has a molecular mass of approximately 140 kDa. USP6 catalyzes the removal of ubiquitin from specific substrates impacting their stability and degradation. You can find USP6 expression in a variety of tissues but it primarily shows in skeletal muscle and brain tissues.
Biological function summary
USP6 regulates numerous cellular processes by modifying protein ubiquitination levels. This protein often interacts with components of the endosomal sorting complex required for transport (ESCRT) playing a part in the regulation of membrane trafficking. Additionally USP6 influences cell signaling pathways by modulating the turnover of receptor proteins important for cell communication.
Pathways
Several cellular networks involve USP6 that control protein degradation and signal transduction. In particular it plays a role in the Wnt signaling pathway impacting cell proliferation and differentiation. The protein also associates with β-catenin through this pathway affecting cellular processes such as transcriptional activation and cell cycle regulation.
Aberrant USP6 expression links with various conditions. It has a connection to aneurysmal bone cysts where its upregulation results in tumor formation due to enhanced osteoclast activity. The USP6 gene fusion with another protein CDH11 is implicated in this disorder altering normal cellular signaling. Furthermore USP6's dysregulation can also relate to certain soft tissue tumors indicating its role in tumorigenesis.