Abcam, ab226210, Anti-DIXDC1 antibody

Size: 100µL
Rabbit Polyclonal DIXDC1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human DIXDC1 aa 600 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DIXDC1 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q155Q3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DIXDC1 also known as Dixin or Ccd1 functions as a cytoplasmic signal transducer involved in the regulation of the Wnt signaling pathway. The protein has a molecular weight of approximately 86 kDa. It is expressed in various tissues with higher expression levels in the central nervous system including the brain. The protein plays a significant role in cellular signaling and cytoskeletal organization impacting different cellular processes.
Biological function summary
DIXDC1 influences cellular dynamics by participating in cell migration and invasion. It acts as a stabilizing component in complexes with other proteins within signaling pathways. The protein interacts with Dishevelled (Dvl) proteins facilitating Wnt signaling. DIXDC1 also contributes to the modulation of the actin cytoskeleton thereby impacting cell morphology and motility.
Pathways
The role of DIXDC1 becomes evident within the canonical Wnt signaling pathway and cytoskeletal reorganization processes. The protein interacts with key components like Dishevelled proteins which are central to Wnt signaling. Moreover DIXDC1 links to the Ras-related C3 botulinum toxin substrate 1 (Rac1) pathway which impacts actin filament dynamics and cellular movement. This positions DIXDC1 as integral in processes governing cellular architecture and signaling.
Abnormal activity or expression levels of DIXDC1 can be associated with neurological disorders such as schizophrenia and cancer progression including glioblastoma. The dysregulation of DIXDC1 affects downstream interactions and pathways such as alterations in Rac1 activity which can contribute to the pathophysiology of these conditions. Understanding how DIXDC1 functions in disease contexts offers potential therapeutic insights.