Abcam, ab228736, Anti-PRDC antibody - C-terminal

Size: 100µL
Rabbit Polyclonal PRDC antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human GREM2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GREM2. The exact immunogen used to generate this antibody is proprietary information.Q9H772

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRDC also known as protein related to DAN and cerberus or GREM2 is a member of the DAN family of cysteine knot secreted proteins. It weighs approximately 24 kDa. PRDC expresses in various tissues with strong presence in the heart lung and kidney among others. Its expression pattern suggests a role in organ development and tissue homeostasis. As a secreted protein PRDC exists outside the cell where it can interact with other molecules in the extracellular environment.
Biological function summary
PRDC functions as an antagonist of bone morphogenetic proteins (BMPs) which are part of the TGF-beta superfamily. By inhibiting BMP signaling PRDC regulates cell differentiation and growth. This protein does not work alone; it often interacts within larger complexes that involve other members of the BMP family. Through this interaction PRDC plays a role in developmental processes and tissue regeneration.
Pathways
PRDC integrates into key signaling cascades such as the BMP signaling pathway and TGF-beta pathway. It modulates the activity of BMPs directly affecting SMAD-dependent signaling. This role places it as a critical player in embryogenesis and organogenesis. Proteins like noggin and chordin also intersect with PRDC within these pathways working together to modulate cellular responses.
Altered PRDC function links to various conditions including fibrodysplasia ossificans progressiva (FOP) and pulmonary hypertension. These diseases highlight the importance of proper BMP signaling modulation by PRDC. In the context of FOP abnormal PRDC expression can exacerbate processes like heterotopic ossification. Proteins such as ACVR1 involved in BMP signaling exhibit interconnected roles with PRDC in these pathological conditions.