Abcam, ab228836, Anti-NOL6 antibody

Size: 100µL
Rabbit Polyclonal NOL6 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Nucleolar protein 6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Nucleolar protein 6. The exact immunogen used to generate this antibody is proprietary information.Q9H6R4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NOL6 also known as nucleolar protein 6 is a nucleolar RNA-associated protein with a mass of roughly 117 kDa. It localizes mainly to the nucleolus and shows high expression in actively dividing cells reflecting its role in ribosomal RNA (rRNA) processing. The NOL6 protein interacts with rRNA during ribosome biogenesis and its presence is notable in developing and differentiating tissues pointing to its involvement in fundamental cell growth and proliferation mechanisms.
Biological function summary
NOL6 participates in ribosomal assembly by interacting with pre-ribosomal particles. It becomes part of the larger ribonucleoprotein complex important for the maturation of the 60S ribosomal subunit. NOL6 ensures the accurate cleavage and modification of precursor rRNA which is essential for functional ribosome construction. This contribution influences protein synthesis rates within the cell impacting overall cellular metabolism and responsiveness to growth signals.
Pathways
Ribosome biogenesis and RNA processing in the nucleolus engage NOL6 extensively. It closely interacts with the rRNA processing pathway and is functionally connected to other nucleolar proteins such as fibrillarin and NOP56. These proteins coordinate for effective ribosome production ensuring the cell's protein synthesis machinery runs smoothly. Through these pathways NOL6 assists in maintaining cellular growth and response to environmental change.
NOL6 has implications in cancer and ribosomopathies conditions tied to defective ribosome biogenesis. Aberrant expression or mutation of NOL6 has been observed in various cancers associating it with dysregulated cell growth. It can also connect to oncogenes like c-Myc which modulates ribosome biogenesis and cell proliferation. Understanding these relationships helps identify potential diagnostic and therapeutic targets providing insights into combating these diseases.