Abcam, ab228957, Anti-YARS2/TyRS antibody

Size: 100µL
Rabbit Polyclonal YARS2/TyRS antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human YARS2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human YARS2. The exact immunogen used to generate this antibody is proprietary information.Q9Y2Z4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
YARS2 also known as TyrRS is a mitochondrial tyrosyl-tRNA synthetase with a molecular mass of approximately 55 kDa. It catalyzes the attachment of tyrosine to its corresponding tRNA a fundamental step for protein synthesis within mitochondria. YARS2 is expressed in various tissues with notable levels in those requiring high mitochondrial activity. It ensures the correct translation of mitochondrial genes by ensuring the specific aminoacylation of tRNA.
Biological function summary
YARS2 plays an essential role in mitochondrial protein biosynthesis a process vital for cellular energy production. As part of the group of aminoacyl-tRNA synthetases it is required for proper mitochondrial function and cellular respiration. Mitochondrial dysfunction due to errors in this enzyme can disrupt cellular homeostasis and energy metabolism leading to severe outcomes.
Pathways
The activity of YARS2 is integral to the oxidative phosphorylation pathway. This pathway involves the production of ATP the energy currency of the cell and requires a coordinated action of multiple proteins including cytochrome c oxidase subunits. YARS2 ensures the synthesis of key proteins necessary for this pathway influencing both energy generation and overall cellular health.
YARS2 mutations relate to mitochondrial myopathy and sideroblastic anemia. These conditions often involve the disruption of normal mitochondrial protein synthesis leading to muscle weakness and compromised red blood cell production. Mutations in related proteins such as MTO1 and TRMU which also influence mitochondrial translation can exacerbate these disorders highlighting the critical role of YARS2 within mitochondrial genetic translation and its clinical significance.