Abcam, ab229120, Anti-PHACTR1 antibody

Size: 100µL
Rabbit Polyclonal PHACTR1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PHACTR1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PHACTR1. The exact immunogen used to generate this antibody is proprietary information.Q9C0D0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PHACTR1 also known as Phosphatase and Actin Regulator 1 plays an important role in cellular processes. This protein weighs approximately 71 kDa. PHACTR1 is expressed in various tissues with high levels in the brain and heart. Functionally this protein interacts with actin and protein phosphatase 1 (PP1) modulating their activities within the cell.
Biological function summary
PHACTR1 regulates the dynamics of the actin cytoskeleton affecting processes like cell motility and shape. Moreover it is part of the PP1 complex where it acts as a regulatory subunit controlling dephosphorylation events. By modulating PP1 activity PHACTR1 influences multiple cellular functions and contributes to maintaining cellular homeostasis.
Pathways
PHACTR1 is involved notably in the actin cytoskeleton organization and signal transduction pathways. It connects with proteins like the RhoA linking it to pathways that control cytoskeletal dynamics. By interacting with or influencing such proteins PHACTR1 integrates signals that control cytoskeletal rearrangements and cellular responses.
PHACTR1 has been linked to coronary artery disease and migraine. In the context of coronary artery disease it is connected to the regulation of endothelial function and vascular response. Studies suggest interactions between PHACTR1 and other proteins involved in these disease processes highlighting its potential as a therapeutic target.