Abcam, ab229648, Anti-GPCR GPR39 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal GPCR GPR39 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GPR39.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GPR39. The exact immunogen used to generate this antibody is proprietary information.O43194

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR39 also known as G-protein coupled receptor 39 is a member of the G-protein coupled receptor (GPCR) family which play important roles in signaling mechanisms in cells. This receptor has a mass of approximately 53 kDa. It is expressed in multiple human tissues with a significant presence in the gastrointestinal tract kidney and pancreas. GPR39 is involved in binding zinc ions which suggests a regulatory role under physiological conditions where zinc concentrations fluctuate.
Biological function summary
GPR39 influences various physiological processes related to metabolic and homeostatic functions in the body. It is not part of a complex but operates as a standalone receptor that activates diverse intracellular pathways upon ligand binding. The receptor has reported roles in regulating appetite influencing glucose metabolism and maintaining energy balance. Through the modulation of different cellular signals GPR39 helps in controlling processes like gastric acid secretion and insulin sensitivity.
Pathways
Researchers recognize GPR39’s involvement in the Wnt signaling and mTOR signaling pathways. In the context of the Wnt pathway GPR39 interfaces through interactions with other signaling molecules and proteins like beta-catenin which underpins its role in cellular growth and differentiation. Meanwhile in the mTOR pathway its interaction influences protein synthesis and cellular metabolism. These pathways highlight the receptor's pivotal role in various biological processes.
GPR39's functional implications extend to conditions such as metabolic syndrome and gastrointestinal disorders. Its regulation of metabolic processes links it to metabolic syndrome where insulin resistance and glucose homeostasis are disrupted. Additionally in gastrointestinal disorders changes in its expression or function relate to conditions like irritable bowel syndrome (IBS). Interactions with proteins such as ghrelin and insulin highlight its extensive influence as these proteins are essential for metabolic and appetite regulation.