Abcam, ab230324, Anti-FUCA1 antibody

Size: 200µL
Rabbit Polyclonal FUCA1 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FUCA1 aa 250-300 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FUCA1 aa 250-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P04066

Properties and Storage Information:
Form-Liquid, Purification technique-Precipitation Ammonium Sulphate, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as 'alpha-L-fucosidase' or more commonly 'FUCA1' works as an enzyme breaking down complex carbohydrates by removing terminal alpha-L-fucose residues. This enzyme weighs approximately 51 kDa. It mainly expresses in tissues such as the liver pancreas and kidney playing a role in glycoprotein metabolism. Sometimes researchers refer to it simply as 'fucosidase' reflecting its central activity in fucose metabolism.
Biological function summary
FUCA1 impacts various cellular functions through its role in glycan processing. This enzyme is not typically part of a larger complex working independently to hydrolyze glycosidic bonds. Its action is important in the catabolism of fucosylated glycoproteins and glycolipids influencing cell signaling and recognition. Alterations in FUCA1 activity can disrupt these processes affecting cellular homeostasis.
Pathways
FUCA1 plays a role in the metabolism of glycosaminoglycans and glycoproteins. It contributes to the lysosomal degradation pathway alongside related enzymes such as beta-galactosidase. FUCA1's activity ensures the correct recycling of glycoproteins maintaining the balance of cellular components. The defect or overactivity of FUCA1 may have cascading effects throughout these pathways linking it with potential metabolic imbalances.
FUCA1 connects closely with fucosidosis a lysosomal storage disorder caused by FUCA1 deficiency. This leads to an accumulation of fucose-containing compounds resulting in progressive neurological decline. Additionally some studies suggest a link between altered FUCA1 expression and certain cancers due to its role in cellular recognition and signaling. In cancer this enzyme's interaction with other glycoprotein-processing enzymes becomes highlighted highlighting the complex interplay within disease contexts.