Abcam, ab230507, Anti-ZFP36L1 antibody

Size: 50µL
Rabbit Polyclonal ZFP36L1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ZFP36L1 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZFP36L1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q07352

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.01% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZFP36L1 also known as TIS11b or BRF1 is a member of the CCCH-type zinc finger protein family. It plays a role in the regulation of mRNA stability by binding to AU-rich elements in the 3' UTR of target mRNAs. ZFP36L1 has a molecular mass of approximately 44 kDa and its expression is widespread in various tissues including the immune system and embryonic tissues. Through its activity ZFP36L1 can modulate the levels of mRNAs and consequently the proteins they encode influencing cellular processes such as proliferation and differentiation.
Biological function summary
ZFP36L1 acts as a post-transcriptional regulator of gene expression. It destabilizes mRNAs leading to their decay and reduced translation into proteins. While ZFP36L1 often functions as a monomer it can also form complexes with other proteins involved in RNA metabolism. As a result ZFP36L1 plays a critical role in the turnover of pro-inflammatory cytokines and growth factors impacting cellular responses to external stimuli. This regulatory function is essential for maintaining normal cellular homeostasis under various physiological conditions.
Pathways
ZFP36L1 integrates into signaling pathways such as MAPK and NF-kB which are important for inflammation and cellular stress responses. Within these pathways ZFP36L1 interacts with other signaling molecules like MK2 and p38 kinase. These interactions help mediate ZFP36L1's role in mRNA decay influencing the expression of genes involved in the immune response and cell survival. Its participation in these pathways highlights the regulatory landscape in which ZFP36L1 operates affecting diverse cellular functions.
ZFP36L1 has been linked to immune-related conditions such as rheumatoid arthritis and certain types of cancer. In rheumatoid arthritis ZFP36L1 contributes to chronic inflammation due to its impact on cytokine mRNA turnover. It interplays with proteins like TNF-alpha which are important in the inflammatory cascade. In cancer aberrant regulation of ZFP36L1 can affect tumor progression through alterations in cell cycle regulation and apoptosis. Understanding the role of ZFP36L1 in these diseases provides insight into potential therapeutic approaches targeting mRNA stability mechanisms.