Abcam, ab230674, Anti-MRP5 antibody [6C6]

Size: 50µL
Mouse Monoclonal MRP5 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ABCC5.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:6C6,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ABCC5.O15440

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from TCS., Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRP5 also known as ABCC5 is part of the ATP-binding cassette (ABC) transporter family. This protein is approximately 162 kDa in mass and is involved in the transport of various molecules across cellular membranes. MRP5 is expressed widely in human tissues with significant expression seen in the brain lung and cardiovascular tissues. It acts as an organic anion transporter and has roles in cellular detoxification and the efflux of cyclic nucleotides and drugs which makes it relevant to pharmacology and chemotherapy resistance.
Biological function summary
MRP5 functions by transporting cyclic nucleotides such as cGMP and cAMP out of cells regulating their intracellular levels. It plays a role in modulating signal transduction processes and is also involved in the regulation of nitric oxide and the maintenance of vascular homeostasis. MRP5 does not form a complex with other proteins for its primary transport function operating largely as an independent transporter in cellular detoxification.
Pathways
MRP5 contributes significantly to the cAMP and cGMP signaling pathways where it influences vascular tone and cardiac function. It associates with proteins such as cGMP-dependent protein kinase through these pathways. Its activity in cyclic nucleotide transport impacts various signal transduction mechanisms that are essential for cell growth and communication.
MRP5 links to conditions like pulmonary hypertension and some forms of drug-resistant cancers. Its role in cyclic nucleotide efflux can affect vascular responses implicating it in pulmonary hypertension's pathogenesis. In the context of cancer increased MRP5 expression can lead to decreased effectiveness of chemotherapeutic agents. This resistance shares a connection with other ABC transporters involved in effluxing drugs out of cells such as P-glycoprotein. Understanding MRP5's role and regulation can offer insights into disease mechanisms and potential therapeutic targets.