Abcam, ab230864, Anti-LENG8 antibody

Size: 50µL
Rabbit Polyclonal LENG8 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LENG8 aa 450-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LENG8 aa 450-700. The exact immunogen used to generate this antibody is proprietary information.Q96PV6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LENG8 also known as Leukocyte Receptor Cluster Member 8 is a protein that plays an important role in immune signaling. The molecular weight of LENG8 is approximately 25 kDa. LENG8 shows expression mainly in immune-related tissues like the spleen and lymph nodes indicating its role in the immune system. Its expression patterns suggest a functional role in immune cell interaction and signaling.
Biological function summary
The actions of LENG8 are tied to immune cell interaction within the leukocyte receptor cluster. It does not work as an isolated protein but participates as part of a broader protein network. This cluster involves several receptors linked to immune modulation. LENG8 possibly influences the regulation of immune responses contributing to maintaining immune homeostasis.
Pathways
Researchers have connected LENG8 to immune-related signaling pathways such as the cytokine receptor signaling pathway. Its involvement here suggests interactions with various cytokine receptors and other leukocyte receptors. These interactions place LENG8 in the broader context of immune cell activation and communication potentially interacting with proteins such as IL-2 and IL-4 which are key players in controlling immune responses.
LENG8's role in immune regulation implies a potential connection to autoimmune diseases like rheumatoid arthritis. Dysfunction or altered expression of LENG8 might influence disease progression due to its impact on immune cell signaling. In rheumatoid arthritis proteins such as TNF-alpha and IL-6 which regulate inflammatory responses might exhibit altered interactions with the pathways that involve LENG8 contributing to the disease pathology.