Abcam, ab231634, Anti-MPP2/DLG2 antibody

Size: 100µg
Rabbit Polyclonal MPP2/DLG2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Mpp2 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Mpp2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9WV34

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab231634 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MPP2 also known as DLG2 (Discs Large Homolog 2) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. It plays a role in maintaining cell polarity and organizing signal complexes at cell junctions. This protein has a mass of approximately 85 kDa. MPP2/DLG2 expresses mainly in the brain particularly in neuronal cells where it contributes to synaptic transmission and plasticity.
Biological function summary
The DLG2 protein acts as a scaffolding protein that organizes other proteins within the synaptic membrane at excitatory synapses. It is part of the heteromeric complex that includes other synaptic proteins facilitating interactions between NMDA receptors and various signaling molecules. By stabilizing these protein interactions DLG2 influences synaptic strength and cellular communication pathways.
Pathways
DLG2 is involved in the regulation of synaptic plasticity which plays an important role in learning and memory. It participates in the NMDA receptor signaling pathway interacting with proteins like PSD-95 which is important for synapse maturation and plasticity. Additionally DLG2 is linked to the MAPK signaling pathway which impacts cell growth division and differentiation.
DLG2 has associations with neurological disorders such as schizophrenia and intellectual disabilities. Its interaction with proteins like SHANK3 which are implicated in neuropsychiatric conditions suggests that dysregulation of DLG2 can lead to abnormal synaptic signaling linked to these disorders. Understanding DLG2's function and connections is important for exploring therapeutic targets in these brain disorders.