Abcam, ab232886, Anti-MRPL1 antibody

Size: 100µg
Rabbit Polyclonal MRPL1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MRPL1 aa 100-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MRPL1 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.Q9BYD6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MRPL1 protein also known as Mitochondrial Ribosomal Protein L1 is an essential component of the mitochondrial ribosome. It weighs approximately 34.1 kDa and plays a critical mechanical role in the synthesis of proteins within mitochondria. MRPL1 is expressed in various tissues with high metabolic activity particularly in the liver muscle and brain reflecting its importance in these energy-demanding areas.
Biological function summary
MRPL1 contributes to mitochondrial protein synthesis by being part of the mitochondrial large ribosomal subunit. It is one of the components that build the ribosome's structure enabling the translation of mitochondrial-encoded proteins. This integration into the ribosomal complex facilitates the accurate translation of mRNA which is necessary for proper mitochondrial function and energy production.
Pathways
MRPL1 functions in pathways related to mitochondrial translation and energy metabolism. It plays a part in the mitochondrial translation pathway a critical component for cellular energy production through oxidative phosphorylation. This pathway largely involves interactions with proteins such as MRPS22 which is part of the small subunit aiding in the synthesis of proteins important for the electron transport chain.
Altered MRPL1 function is associated with mitochondrial diseases and metabolic disorders. Mutations or defects in MRPL1 can lead to conditions like cardiomyopathy and MELAS syndrome (Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-like episodes). In these diseases the relationship between MRPL1 and the malfunctioning of mitochondrial-encoded proteins is evident and it interacts with other mRNAs translated in mitochondria impacting cellular energy balance.