Abcam, ab233827, Anti-TLL1 antibody [4H8C1]

Size: 100µg
Mouse Monoclonal TLL1 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TLL1 aa 850 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4H8C1,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TLL1 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O43897

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TLL1 also known as tolloid-like protein 1 is a metalloprotease with an approximate mass of 105 kDa. TLL1 belongs to the astacin family of zinc-dependent metalloproteinases. It cleaves specific protein substrates playing a critical role in tissue remodeling and development. This protein is mainly expressed in the heart lungs and skeletal tissue indicating its importance in these organs.
Biological function summary
The functions of tolloid-like protein 1 are essential for embryonic development particularly in heart morphogenesis. TLL1 forms part of a protein complex that regulates the activation of latent growth factors. It facilitates the maturation of certain extracellular matrix components by cleaving procollagen C-propeptides. Such activity is central to ensuring proper extracellular matrix organization and subsequent tissue integrity.
Pathways
The enzymatic actions of TLL1 integrate into critical signaling pathways such as the Transforming Growth Factor-beta (TGF-β) and Bone Morphogenetic Protein (BMP) signaling pathways. TLL1 modulates these pathways by processing various latent growth factors. It shares functional similarities with related proteins like BMP1 another known metalloprotease by orchestrating cellular communication and tissue formation processes which are vital for proper cellular events.
Tolloid-like protein 1 has been associated with congenital heart defects due to its indispensable role in heart development. Mutations or malfunctions in TLL1 can lead to maladaptive morphogenesis of cardiac tissues. Moreover research indicates a link between TLL1 and fibrotic conditions. Alterations in its activity can disrupt normal tissue fibrosis processes and involve proteins like TGF-β leading to pathological fibrosis in tissues such as the heart and lungs.