Abcam, ab234700, Anti-INTS9 antibody

Size: 100µL
Rabbit Polyclonal INTS9 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human INTS9 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human INTS9 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NV88

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Integrator Complex Subunit 9 commonly known as INTS9 plays a mechanical role in RNA polymerase II transcription. INTS9 has a molecular weight of approximately 110 kDa. It is expressed in various tissues with noticeable levels in the reproductive and immune systems. Researchers often refer to it by its alternate names such as Int9 or RC74. Its expression is not limited to a single cell type or tissue suggesting a broad functional role across the body.
Biological function summary
INTS9 forms part of the larger Integrator complex which interacts with the carboxy-terminal domain of RNA polymerase II. The complex is essential for processing small nuclear RNAs (snRNAs) influencing the transcription termination of snRNAs. INTS9 contributes to the regulation of transcription and RNA processing particularly in the modification of RNA molecules to make them functional. As a member of the Integrator complex it interacts with various subunits to ensure proper RNA polymerase II function.
Pathways
INTS9 is part of important cellular processes like transcription regulation and RNA processing. It plays a role in the snRNA-processing pathway where it ensures accurate transcription termination and RNA maturation. Proteins such as RNA polymerase II and other Integrator subunits like INTS11 work closely with INTS9 within these pathways. This coordination ensures the maintenance of cellular homeostasis and the accurate synthesis of RNA components necessary for cellular operations.
INTS9's role links to conditions that involve transcriptional dysregulation and RNA processing errors. Mutations in INTS9 have connections to neurological disorders as proper RNA processing is critical for neural function. Diseases like neurodevelopmental disorders show correlation with defective RNA transcription pathways involving RNA polymerase II. INTS9's interaction with proteins such as INTS11 and RNA polymerase II suggests a complex interplay where disruption could contribute to these transcription-related illnesses.