Abcam, ab234835, Anti-FAU / 40S ribosomal protein S30 antibody

Size: 100µL
Rabbit Polyclonal RS30 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FAU.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human FAU.P62861

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FAU protein also known as 40S ribosomal protein S30 plays an important role in the formation of ribosomes which are essential for protein synthesis. With a molecular mass of approximately 13 kDa it contributes to the small subunit of the ribosome assembly. This protein is expressed in several tissues including the liver kidney and pancreas indicating its ubiquitous role in maintaining cellular machinery. The FAU gene encodes this protein and its expression shows variation depending on tissue type and physiological conditions.
Biological function summary
FAU / 40S ribosomal protein S30 is a component of the eukaryotic ribosomal 40S subunit participating in the translation process. It forms part of the ribosome complex with other ribosomal proteins and RNA which together drive the synthesis of proteins in cells by translating mRNA. Its role in ribosome assembly emphasizes its involvement in the overall cellular function of protein production which is fundamental for cell growth and division.
Pathways
FAU protein integrates mainly within the process of translational initiation. The process includes various steps where the protein joins other ribosomal proteins and initiation factors to form functional ribosomes that start the translation of mRNA. FAU's interactions include associations with proteins like eIF3 an essential initiation factor which facilitates the accurate translation start site selection. This engagement ensures that FAU is integral to both the regulation and efficiency of protein synthesis a critical cellular activity.
FAU / 40S ribosomal protein S30 connects with certain cancers reflecting its importance in cell proliferation. Changes in FAU expression levels associate with malignant transformation particularly in liver cancer suggesting its potential role in tumor development. It also interacts with P53 a well-known tumor suppressor protein highlighting its relevance in apoptosis and cancer-related pathways. Additionally its altered regulation associates with ribosomopathies which are disorders arising from defects in ribosomal function underlining its essential contributions to cellular homeostasis and health.