Abcam, ab234885, Anti-PHLDB2 antibody

Size: 100µL
Rabbit Polyclonal PHLDB2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PHLDB2 aa 700-1050.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PHLDB2 aa 700-1050. The exact immunogen used to generate this antibody is proprietary information.Q86SQ0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PHLDB2 also known as pleckstrin homology-like domain family B member 2 plays important mechanical roles in cellular signaling and structural processes. It weighs around 122 kDa and expresses in various tissues including the brain and immune cells. PHLDB2 interacts with the plasma membrane through its pleckstrin homology domain playing a regulatory role in cytoskeletal arrangements and cellular adhesion.
Biological function summary
The protein interacts within cellular environments to modulate cell polarity and migration often involving complex formations. PHLDB2 associates with actin filaments and contributes to directed cell movement. It helps regulate immune responses by influencing antibody production and cell surface receptor dynamics impacting how cells respond to external signals.
Pathways
PHLDB2 participates actively in the PI3K/AKT signaling pathway and cytoskeleton regulation. It partners with other proteins like AKT to control cell growth survival and metabolism. The protein also interacts within the Wnt signaling pathway aiding in further modulation of cellular polarization and movement linking it to cell fate decisions in development.
PHLDB2 is linked to glioblastoma and systemic lupus erythematosus through its influence on cellular migration and immune regulation. In glioblastoma aberrant expression levels of PHLDB2 affect tumor cell invasion and metastasis often involving interactions with proteins such as integrins. In systemic lupus erythematosus PHLDB2 dysregulation impacts immune cell functions and inflammatory responses connecting to proteins like IL-6 in the immune signaling pathways.