Abcam, ab235520, Anti-IFRD2 antibody

Size: 100µL
Rabbit Polyclonal IFRD2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IFRD2 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IFRD2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q12894

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IFRD2 also known as Interferon-Related Developmental Regulator 2 is a protein with a mass of approximately 35 kDa. This protein belongs to the IFRD family and is expressed in various tissues with higher levels observed in the brain and muscle tissues. It participates in transcription regulation and signal transduction. IFRD2's expression is modulated in response to different cytokines and growth factors indicating its involvement in cell signaling and development.
Biological function summary
IFRD2 influences cell differentiation and development by regulating gene expression. It forms part of a larger complex interacting with other proteins involved in transcriptional modulation. This protein plays a role in cellular responses to environmental changes and cellular growth. Its presence contributes to the fine-tuning of transcriptional machinery essential for proper cellular function.
Pathways
IFRD2 is involved in the cellular response to stress and developmental pathways. It participates in the interactions between nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and histone deacetylases (HDACs) important for inflammatory response regulation. IFRD2 affects these pathways by modulating the activity and interactions of proteins within these signaling networks.
IFRD2 exhibits connections to neurodegenerative diseases and muscle disorders. Alterations in IFRD2 expression have shown links to conditions such as Alzheimer's disease where it interacts with tau proteins affecting neurofibrillary tangle formation. In muscle disorders variations in IFRD2 levels correlate with muscle atrophy in association with proteins like myostatin influencing muscle mass and function. Its role in these conditions highlights its potential target for therapeutic intervention.