Abcam, ab109494, Anti-S100 alpha 2/S100A2 antibody [EPR5392]

Size: 100µL / 1mL
Anti-S100 alpha 2/S100A2 antibody [EPR5392] (ab109494) is a rabbit monoclonal antibody detecting S100 alpha 2/S100A2 in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, ICC/IF . Suitable for Human . - Biophysical QC for unrivalled batch-batch consistency - Over 10 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5392,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IP, WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-S100 alpha 2/S100A2 antibody [EPR5392] (ab109494) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples.
What is the molecular weight of S100 alpha 2/S100A2?
Anti-S100 alpha 2/S100A2 [EPR5392] (ab109494) specifically detects a band for S100 alpha 2/S100A2 (UniProt: P29034) at a molecular weight of 11kDa.
Trusted by the scientific community
Anti-S100 alpha 2/S100A2 [EPR5392] (ab109494) was first used in a scientific publication in 2011 and has been cited over 10 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR5392] also available for your convenience: ab109494, Carrier free -
ab247877
, PE -
ab306147
, APC -
ab306148
, HRP -
ab306149
, Alkaline Phosphatase -
ab308929
, Alexa Fluor® 488 -
ab309858
, Alexa Fluor® 647 -
ab310226
, Alexa Fluor® 594 -
ab310674
, Alexa Fluor® 555 -
ab312204
, Alexa Fluor® 568 -
ab312693
, Alexa Fluor® 750 -
ab320956
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
S100 alpha 2 also known as S100A2 or CAN19 is a calcium-binding protein that plays a role in the regulation of cell functions. It's part of the S100 protein family and has a mass of approximately 11 kDa. S100A2 is expressed in a variety of tissues including epidermal cells and lung tissue suggesting its involvement in diverse cellular processes. The presence in these tissues indicates a potential role in both skin biology and respiratory system functions.
Biological function summary
S100A2 influences cell proliferation differentiation and apoptosis. It acts by modulating the activity of target proteins through a calcium-dependent mechanism. Though S100A2 is not known to form a complex with other proteins for its function it interacts with key cell growth regulators affecting cellular responses to external signals. The precise modulation of these processes implicates S100A2 in the maintenance of normal tissue homeostasis and cell cycle regulation.
Pathways
S100A2 participates in signal transduction pathways such as the MAPK/ERK and p53 pathways. In the MAPK/ERK pathway S100A2 regulates cell cycle progression and cellular responses to growth factors. Additionally in the p53 pathway S100A2 plays a role in apoptosis and tumor suppression. S100A2's function links it to interaction with critical proteins such as p53 influencing both stress response and genomic stability.
S100A2 relates to cancer progression and pulmonary diseases. Altered expression levels of S100A2 have been observed in lung cancer and some skin cancers where it may act as a tumor suppressor. In pulmonary conditions its expression affects tissue responses under pathological states. The interaction of S100A2 with proteins like p53 in these disorders suggests a pivotal role in mediating stress responses and regulating tumor growth providing potential therapeutic targets.