Abcam, ab191412, Anti-OATP5A1 antibody [EPR14395(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal OATP5A1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14395(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OATP5A1 also known as Organic Anion Transporting Polypeptide 5A1 or SLCO5A1 is a member of the solute carrier organic anion transporter family. This protein helps transport a wide variety of molecules including drugs hormones and waste across cell membranes. It weighs approximately 87 kDa. Researchers have observed its expression in several tissues which include the brain heart and placenta. Its role as a transporter makes it important for maintaining cellular homeostasis by facilitating substance exchange within the body.
Biological function summary
OATP5A1 participates in the cellular uptake of various endogenous and exogenous substrates. Although not a part of a larger protein complex OATP5A1 works in concert with other transporters and cellular components to contribute to effective intracellular transport mechanisms. It regulates the concentration of substances within cells supporting key physiological processes such as hormone regulation and drug metabolism impacting how these substances are processed and utilized.
Pathways
OATP5A1 plays significant roles in two important biological pathways: drug metabolism and hormone regulation. The protein's activity influences drug disposition and pharmacokinetics interacting with proteins like cytochrome P450 enzymes along the way. Furthermore OATP5A1 helps drive hormone regulatory pathways alongside proteins such as transporters from the same SLCO family facilitating the appropriate biological responses necessary for maintaining health.
OATP5A1 has links to cancer and multi-drug resistance. Abnormal expression or dysfunction of this transporter can alter drug accumulation in cells affecting chemotherapy's effectiveness and potentially leading to treatment-resistant cancer types. Similarly in the context of drug resistance studies indicate its association with other transporter proteins like P-glycoprotein emphasizing its function in mediating how cells react to pharmacological treatments. Understanding OATP5A1's behavior better could therefore illuminate target pathways for overcoming treatment resistance.