CST, 14672T, IMP2 (D4R2F) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying IMP-2. Validated for Western Blotting,Flow Cytometry (Fixed/Permeabilized). Available in 2 sizes. Highly specific and rigorously validated in-house, IMP2 (D4R2F) Rabbit Monoclonal Antibody (CST #14672) is ready to ship. Product Usage Information Western Blotting: 1:1000 Flow Cytometry (Fixed/Permeabilized): 1:1600 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Flow Cytometry (Fixed/Permeabilized) Specificity / Sensitivity IMP2 (D4R2F) Rabbit Monoclonal Antibody recognizes endogenous levels of total IMP2 protein. This antibody recognizes both the 66 kDa isoform 1 and the 62 kDa isoform 2. This antibody may cross-react with an unidentified protein of 40 kDa. Species Reactivity: Human, Mouse, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human IMP2 protein. Background Insulin-like growth factor-II mRNA-binding proteins (IMPs) belong to a family of zipcode-binding proteins (1,2). Three members of this family, IMP1, IMP2, and IMP3, have been identified (1,2). They contain two RNA recognition motifs, four K homology domains, and were found to function in mRNA localization, turnover, and translation control (1,2). Research studies have implicated these proteins in a variety of physiological and pathological processes, such as growth and development (3), testicular neoplasia (4), and melanocytic neoplasia (5). A well-characterized polymorphism in the corresponding gene is associated with susceptibility to type 2 diabetes in specific ethnic populations (6). Alternate Names Hepatocellular carcinoma autoantigen p62; IF2B2; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IGF2BP2; IMP-2; IMP2; insulin like growth factor 2 mRNA binding protein 2; insulin-like growth factor 2 mRNA binding protein 2; Insulin-like growth factor 2 mRNA-binding protein 2; p62; VICKZ family member 2; VICKZ2 Specification REACTIVITY: H M Mk SENSITIVITY: Endogenous MW (kDa): 66, 62 Source/Isotype: Rabbit IgG