CST, 15356S, NSDHL (F3P8W) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying NSDHL. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, NSDHL (F3P8W) Rabbit Monoclonal Antibody (CST #15356) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity NSDHL (F3P8W) Rabbit Monoclonal Antibody recognizes endogenous levels of total NSDHL protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human NSDHL protein. Background NAD(P) dependent steroid dehydrogenase-like (NSDHL) is an enzyme involved in the late stages of cholesterol biosynthesis (1). Mutations in the gene are associated with the X-linked conditions CHILD (congenital hemidysplasia with ichthyosiform erythroderma and limb defects) and CK syndromes (2,3). Elevated NSDHL expression has been found in several cancer types, including breast, gastric, pancreatic, and multiple myeloma, and can be a potent driver of metastasis and predictor of poor prognosis (4-8). Â Alternate Names epididymis secretory sperm binding protein; H105E3; NAD(P) dependent steroid dehydrogenase-like; NAD(P) dependent steroid dehydrogenase-like protein transcript; NSDHL; Protein H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; XAP104 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 40 Source/Isotype: Rabbit IgG