CST, 17275T, MSR1 (D8K4E) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MSR1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MSR1 (D8K4E) Rabbit Monoclonal Antibody (CST #17275) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity MSR1 (D8K4E) Rabbit Monoclonal Antibody recognizes endogenous levels of total MSR1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu319 of human MSR1 protein. Background Macrophage Scavenger receptor types I and II (MSR1, also known as SCARA1) are members of the class A macrophage scavenger receptor family. These proteins bind large quantities of modified lipoproteins and promote endocytosis. Upregulation of MSR1 in infiltrating myeloid cells may mediate clearance of specific damage signals in response to tissue injury, including ischemic stroke (1). MSR1 germline mutations are also associated with increased prostate cancer susceptibility in some patient cohorts (2). MSR1 is observed to be upregulated in differentiated THP-1 cells (3). Alternate Names CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; macrophage scavenger receptor type III; Macrophage scavenger receptor types I and II; MSR1; MSRE; phSR1; phSR2; SCARA1; Scavenger receptor class A member 1; scavenger receptor class A, member 1; SR-A; SR-AI; SR-AII; SR-AIII; SRA Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 70-90 Source/Isotype: Rabbit IgG