CST, 19046T, PSD93 (D4Z4D) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PSD-93. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, PSD93 (D4Z4D) Rabbit Monoclonal Antibody (CST #19046) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity PSD93 (D4Z4D) Rabbit Monoclonal Antibody recognizes endogenous levels of total PSD93 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro321 of human PSD93 protein. Background Postsynaptic Density Protein 93 (PSD93) is a member of the PSD subfamily of the membrane-associated guanylate kinase (PSD-MAGUK) proteins. Structurally, it most closely resembles PSD95, consisting of an N-terminal variable segment followed by three PDZ domains, an SH3 domain, and an inactive guanylate kinase (GK) domain (1,2). PSD93 is expressed in neuronal cells and located at the synapse where it interacts with neuronal receptors and proteins including the NMDA receptor (2-4), K channels (5,6), and the AMPA receptor (7) to regulate their membrane localization and neuronal signaling. Research studies have implicated PSD93 in postsynaptic related persistent pain induction, making PSD93 a potential target for treatment of this syndrome (3). Alternate Names Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-110; discs large MAGUK scaffold protein 2; discs, large homolog 2 (Drosophila); discs, large homolog 2, chapsyn-110; Disks large homolog 2; DKFZp781D1854; DKFZp781E0954; DLG2; FLJ37266; MGC131811; Postsynaptic density protein PSD-93; PPP1R58; protein phosphatase 1, regulatory subunit 58; PSD-93; PSD93 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 110 Source/Isotype: Rabbit IgG