CST, 19325T, STRIP1/FAM40A (E8J6I) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying STRIP1/FAM40A. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, STRIP1/FAM40A (E8J6I) Rabbit Monoclonal Antibody (CST #19325) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity STRIP1/FAM40A (E8J6I) Rabbit Monoclonal Antibody recognizes endogenous levels of total STRIP1/FAM40A protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human STRIP1/FAM40A protein. Background STRIP1/FAM40A (family with sequence similarity 40, member A) is a component of the STRIPAK complex. STRIPAK is a multi-protein complex that plays important roles in various biological processes, particularly in cellular signaling, and regulates several signaling pathways that are critical for cellular processes such as cell proliferation, migration, and survival. It acts as a scaffold for various signaling proteins, facilitating their interactions and modulating their activities (1). The STRIPAK complex influences the organization and dynamics of the cytoskeleton, which is essential for maintaining cell shape, movement, and intracellular transport. It plays a role in establishing and maintaining cell polarity, which is crucial for proper cell function and tissue organization. The complex is implicated in the regulation of cell-cell adhesion, which is fundamental for tissue integrity and function (2). One of the major functions of the STRIPAK complex is to anchor and regulate the activity of PP2A, a serine/threonine protein phosphatase that dephosphorylates various proteins involved in signal transduction and cell cycle control. In the brain, the STRIPAK complex has been linked to neuronal development and synaptic function, playing a role in neural circuit formation and plasticity (2). Alternate Names 6330569M22Rik; FA40A; FAM40A; family with sequence similarity 40, member A; FAR11 factor arrest 11 homolog A; FAR11A; FLJ14743; homolog of yeast FAR11 protein 1; hypothetical protein LOC85369; KIAA1761; MGC148091; Protein FAM40A; RP4-773N10.1; striatin interacting protein 1; Striatin-interacting protein 1; STRIP1; STRP1 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 96 Source/Isotype: Rabbit IgG