CST, 20226S, MMD (E4U4G) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MMD. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MMD (E4U4G) Rabbit Monoclonal Antibody (CST #20226) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity MMD (E4U4G) Rabbit Monoclonal Antibody recognizes endogenous levels of total MMD protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human MMD protein. Background MMD (monocyte to macrophage differentiation factor), also known as PAQR11, is a member of the PAQR (progestin and AdipoQ receptor) family that was identified in a screen based on differential expression in macrophages compared to monocyte progenitors (1). MMD/PAQR11 has seven transmembrane domains and is localized to the Golgi apparatus (2). It can form a complex with Ras and activate ERK signaling (2). Knockdown of MMD/PAQR11 inhibited monocyte differentiation and alleviated progression of collagen-induced rheumatoid arthritis (3). Expression of MMD/PAQR11 has been associated with epithelial-mesenchymal transition (EMT) and metastasis (4). Studies have also found that it can regulate starvation-mediated lipolysis in white adipose tissue and deletion of PAQR11 in mice leads to resistance in high-fat diet-induced obesity (5). Alternate Names macrophage maturation-associated; MMA; MMD; MMD1; monocyte to macrophage differentiation associated; Monocyte to macrophage differentiation factor; Monocyte to macrophage differentiation protein; monocyte to macrophage differentiation-associated; PAQR11; PAQRB; Progestin and adipoQ receptor family member 11; Progestin and adipoQ receptor family member XI Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 22 Source/Isotype: Rabbit IgG