CST, 31504S, IMP2 (D4R2F) Rabbit Monoclonal Antibody (Alexa Fluor® 647 Conjugate)

Monoclonal Antibody for studying IMP-2. Validated for Flow Cytometry (Fixed/Permeabilized). Highly specific and rigorously validated in-house, IMP2 (D4R2F) Rabbit Monoclonal Antibody (Alexa Fluor^® 647 Conjugate) (CST #31504) is ready to ship. Product Usage Information Flow Cytometry (Fixed/Permeabilized): 1:50 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Flow Cytometry (Fixed/Permeabilized) Specificity / Sensitivity IMP2 (D4R2F) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Human, Mouse, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human IMP2 protein. Background Insulin-like growth factor-II mRNA-binding proteins (IMPs) belong to a family of zipcode-binding proteins (1,2). Three members of this family, IMP1, IMP2, and IMP3, have been identified (1,2). They contain two RNA recognition motifs, four K homology domains, and were found to function in mRNA localization, turnover, and translation control (1,2). Research studies have implicated these proteins in a variety of physiological and pathological processes, such as growth and development (3), testicular neoplasia (4), and melanocytic neoplasia (5). A well-characterized polymorphism in the corresponding gene is associated with susceptibility to type 2 diabetes in specific ethnic populations (6). Alternate Names Hepatocellular carcinoma autoantigen p62; IF2B2; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IGF2BP2; IMP-2; IMP2; insulin like growth factor 2 mRNA binding protein 2; insulin-like growth factor 2 mRNA binding protein 2; Insulin-like growth factor 2 mRNA-binding protein 2; p62; VICKZ family member 2; VICKZ2 Specification REACTIVITY: H M Mk SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG