CST, 32041S, CEMIP (E8Y4R) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying KIAA1199. Validated for Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, CEMIP (E8Y4R) Rabbit Monoclonal Antibody (CST #32041) is ready to ship. Product Usage Information Immunofluorescence (Immunocytochemistry): 1:200 - 1:800 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Immunofluorescence (Immunocytochemistry) Specificity / Sensitivity CEMIP (E8Y4R) Rabbit Monoclonal Antibody recognizes endogenous levels of total CEMIP protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human CEMIP protein. Background CEMIP (KIAA1199, HYBID) was originally described in patients affected by nonsyndromic hearing loss due to point mutations (1). One important role of the protein is the catabolic metabolism of hyaluronan by binding and depolymerizing the high molecular weight hyaluronan to low molecular weight hyaluronan, which contributes to cancer progression and inflammatory disease development (2,3). CEMIP further facilitates cancer progression by promoting WNT/β-catenin, EGFR, and calcium signaling pathways through direct interaction with pathway components (4-7). Aberrant high expression of CEMIP is associated with various types of cancer, where it plays key roles in tumor initiation, progression, metastasis, and epithelial-mesenchymal transition (EMT) (8). High levels of secreted CEMIP are found in inflammatory arthritis, osteoarthritis, atherosclerosis, and inflammatory bowel disease (9,10). Gene knockdown of CEMIP reduces progression of these diseases. CEMIP is a potential target for cancer and inflammatory arthritis management (11,12). Alternate Names CCSP1; cell migration inducing hyaluronan binding protein; cell migration inducing hyaluronidase 1; cell migration inducing protein, hyaluronan binding; Cell migration-inducing and hyaluronan-binding protein; CEMIP; colon cancer secreted protein 1; hyaluronan-binding protein involved in hyaluronan depolymerization; HYBID; KIAA1199; TMEM2L; transmembrane protein 2-like Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 170 Source/Isotype: Rabbit IgG