CST, 32417S, SDHA (D6J9M) Rabbit Monoclonal Antibody (InTraSeq™ 3' Conjugate 3088)

Monoclonal Antibody for studying SDHA. Validated for Single Cell Analysis - InTraSeq™ 3'. Highly specific and rigorously validated in-house, SDHA (D6J9M) Rabbit Monoclonal Antibody (InTraSeq^™ 3' Conjugate 3088) (CST #32417) is ready to ship. Storage Supplied in PBS (pH 7.2), 2 mM EDTA, 0.05% Triton X-100, 2 mg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody . Protocol Available protocols: Single Cell Analysis - InTraSeq™ 3' Specificity / Sensitivity SDHA (D6J9M) XP Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly166 of human SDHA protein. Background Succinate dehydrogenase (SDH), also known as Complex II or succinate:quinone oxidoreductase, is a key component of the citric acid cycle and the electron transport chain (1). Specifically, it is involved in the oxidation of succinate (2). SDH consists of four subunits: SDHA, SDHB, SDHC, and SDHD (3). Research studies have shown that defects in SDHA cause complex II deficiency (2). In addition, investigators have observed reduction of SDHA in the striatum of patients with Huntington's disease (3), and reduction of SDHB, SDHC, and SDHD in paragangliomas and phenochromocytomas (4,5). Alternate Names CMD1GG; DHSA; Flavoprotein subunit of complex II; Fp; FpSDH; PGL5; SDH1; SDH2; SDHA; SDHF; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex flavoprotein subunit; succinate dehydrogenase complex flavoprotein subunit A; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) Specification REACTIVITY: H M SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG