CST, 33401T, LAMP3/CD208 (E8T2T) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LAMP3 mouse. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, LAMP3/CD208 (E8T2T) Rabbit Monoclonal Antibody (CST #33401) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:100 - 1:400 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 91340 . Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity LAMP3/CD208 (E8T2T) Rabbit Monoclonal Antibody recognizes endogenous levels of total LAMP3/CD208 protein. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn257 of mouse LAMP3/CD208 protein. Background Lysosome-associated membrane proteins (LAMPs) are a family of proteins present predominantly on the membrane of lysosomes. Five members have been identified so far (LAMP1, LAMP2, LAMP3, CD68/Macrosialin/LAMP4, and BAD-LAMP/LAMP5). LAMP proteins are involved in many different aspects of cell biology and can influence cellular processes, such as phagocytosis, autophagy, lipid transport, and aging. Their expression varies among different tissues (1). LAMP3, also known as CD-LAMP and CD208, is highly expressed only in certain cell types and differentiation stages. LAMP3 is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as a marker of human DC maturation, but is not expressed by DCs in mouse (2-4). Its expression is associated with poor prognosis of certain tumors, and the locus where it is encoded was identified as a risk factor for Parkinson's disease (PD) (5). Alternate Names 1200002D17Rik; Cd208; DC LAMP; DC-L; DC-LAMP; DC-lysosome-associated membrane glycoprotein; DCLAMP; dendritic cells-lysosome associated membrane glycoprotein; LAMP; LAMP-3; Lamp3; Lysosomal-associated membrane protein 3; Lysosome-associated membrane glycoprotein 3; TSC40; TSC403 Specification REACTIVITY: M SENSITIVITY: Endogenous (IHC-P) Source/Isotype: Rabbit IgG