CST, 3828S, Forskolin

Chemical Modulators for studying in the research area. Product Usage Information For 30 mM stock, reconstitute 10 mg in 812 μl DMSO. Storage Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. Background Forskolin, a naturally occurring diterpene from the Indian plant, , activates adenylate cyclase, and thus increases the intracellular cAMP concentration (1). The second messenger cAMP activates cAMP-dependent protein kinase (PKA or cAPK) and controls many cellular mechanisms such as gene transcription, ion transport and protein phosphorylation (2). Alternate Names adenylyl cyclase; Coleonol; Colforsin; cyclic AMP; gene transcription; ion transport; protein phosphorylation