CST, 38428T, CD43 (MT1) Mouse Monoclonal Antibody

Monoclonal Antibody for studying sialophorin. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CD43 (MT1) Mouse Monoclonal Antibody (CST #38428) is ready to ship. Product Usage Information IHC Leica Bond: 1:50 - 1:200 Immunohistochemistry (Paraffin): 1:50 Storage Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody. Note: This product is only available in the format listed above. We are unable to provide this in a carrier free, custom formulation. Protocol Available protocols: IHC Leica Bond, Immunohistochemistry (Paraffin) Specificity / Sensitivity CD43 (MT1) Mouse Monoclonal Antibody recognizes endogenous levels of CD43 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with human lymphocytes. Background CD43, also known as leukosialin and sialophorin, is a type I transmembrane sialylated, negatively charged mucin that is expressed on the surface of most hematopoietic cells (1,2). CD43 plays an important role in T lymphocyte function by negatively regulating antigen-specific T cell activation and interfering with cellular adhesion and proliferation (2,3). It also has been reported that CD43 is involved in viral clearance (3). Aberrant expression of CD43 is associated with several diseases, such as Wiskott-Aldrich syndrome and acute leukemia (3,4). Alternate Names CD43; CD43 cytoplasmic tail; CD43-ct; CD43ct; Galactoglycoprotein; GALGP; GPL115; LEUK; Leukocyte sialoglycoprotein; Leukosialin; LSN; Sialophorin; sialophorin (gpL115, leukosialin, CD43); sialophorin (leukosialin, CD43); SPN Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Mouse IgG1