CST, 43861S, Napsin A (D2G1Y) Rabbit Monoclonal Antibody (IF Formulated)

Monoclonal Antibody for studying Napsin A. Validated for Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, Napsin A (D2G1Y) Rabbit Monoclonal Antibody (IF Formulated) (CST #43861) is ready to ship. Product Usage Information Immunofluorescence (Immunocytochemistry): 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Immunofluorescence (Immunocytochemistry) Specificity / Sensitivity Napsin A (D2G1Y) Rabbit Monoclonal Antibody (IF Formulated) recognizes endogenous levels of total napsin A protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human napsin A protein. Background Napsin A is an aspartic proteinase that is expressed in normal lung and kidney (1). In the lung, napsin A is expressed by type II pneumocytes and alveolar macrophages, where it plays a role in processing surfactant protein B (2). Napsin A is expressed in lung adenocarcinomas, where it can be used to identify primary and metastatic lesions with greater sensitivity compared to TTF-1 (3,4). Napsin A expression has also been described in other types of cancer, such as kidney and thyroid cancer (5). Alternate Names Asp 4; ASP4; Aspartyl protease 4; KAP; Kdap; kidney-derived aspartic protease-like protein; NAP1; NAPA; NAPSA; napsin A aspartic peptidase; Napsin-1; Napsin-A; pronapsin A; SNAPA; TA01/TA02 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG