CST, 45008S, CXCL10 (F9N8I) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CXCL10. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CXCL10 (F9N8I) Rabbit Monoclonal Antibody (CST #45008) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:200 - 1:800 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 33892 . Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity CXCL10 (F9N8I) Rabbit Monoclonal Antibody recognizes endogenous levels of total CXCL10 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human CXCL10 protein. Background C-X-C motif chemokine ligand 10 (CXCL10, IP-10) is a chemokine produced by several cell types and induced in response to pro-inflammatory cytokines, such as IFN-gamma and TNF-alpha (1,2). CXCL10 binds to the chemokine receptor CXCR3 and induces calcium flux and cell migration (3). The CXCR3 protein is normally expressed on activated CD4 T cells and NK cells, which can produce pro-inflammatory cytokines, including IFN-gamma and TNF-alpha (3,4). As a result, these molecules act in an amplification loop to promote immune responses in the contexts of both autoimmunity and a tumor immune response (5,6). Alternate Names 10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; C-X-C motif chemokine ligand 10; C7; chemokine (C-X-C motif) ligand 10; crg-2; CXCL10; CXCL10(1-73); CXL10; gamma IP10; Gamma-IP10; gIP-10; IFI10; INP10; interferon-inducible cytokine IP-10; IP-10; IP10; mob-1; protein 10 from interferon (gamma)-induced cell line; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; Small-inducible cytokine B10 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG