CST, 50068T, Vasopressin (D8T3K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Vasopressin. Validated for Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, Vasopressin (D8T3K) Rabbit Monoclonal Antibody (CST #50068) is ready to ship. Product Usage Information Immunofluorescence (Frozen): 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Immunofluorescence (Frozen) Specificity / Sensitivity Vasopressin (D8T3K) Rabbit Monoclonal Antibody recognizes endogenous levels of total Vasopressin protein. Presumed non-specific labeling of retinal plexiform layers has been observed by immunofluorescence. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro155 of human Vasopressin protein. Background Vasopressin is a neuroendocrine peptide that is released to the circulation by magnocellular neurons whose cell bodies are mainly found in the paraventricular and the supraoptic nuclei of the hypothalamus. It was first isolated from pituitary gland extracts and synthesized in 1951 (1). Vasopressin acts by activating G protein-coupled, V1a, V1b (also known as V3) and V2 receptors and plays a fundamental role in the maintenance of water homeostasis. One of its main functions is body water retention (2), hence its alternative name antidiuretic hormone or ADH. Vasopressin also leads to increased arterial blood pressure by raising peripheral vascular resistance (3). Vasopressin is also involved in other physiological processes such as acute heart failure (4), pain (5), and metabolic syndrome (6). Alternate Names ADH; antidiuretic hormone; Arg-vasopressin; arginine vasopressin; Arginine-vasopressin; ARVP; AVP; AVP-NPII; AVRP; Copeptin; NEU2; neurohypophyseal; Neurophysin 2; Neurophysin-II; prepro-arginine-vasopressin-neurophysin II; prepro-AVP-NP II; vasopressin; Vasopressin-neurophysin 2-copeptin; vasopressin-neurophysin II-copeptin; VP Specification REACTIVITY: M SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG