CST, 50384T, IgA (N1CLA) Mouse Monoclonal Antibody

Monoclonal Antibody for studying IGHA2/IGHA1. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, IgA (N1CLA) Mouse Monoclonal Antibody (CST #50384) is ready to ship. Product Usage Information IHC Leica Bond: 1:800 - 1:3200 Immunohistochemistry (Paraffin): 1:400 - 1:1600 Storage Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody. Note: This product is only available in the format listed above. We are unable to provide this in a carrier free, custom formulation. Protocol Available protocols: IHC Leica Bond, Immunohistochemistry (Paraffin) Specificity / Sensitivity IgA (N1CLA) Mouse Monoclonal Antibody recognizes endogenous levels of IgA protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to 129 amino acids of the heavy chain constant region of human immunoglobulin A molecule. Background Immunoglobulin A (IgA) is one of the five major human immunoglobulin isotypes and the most abundant immunoglobulin in the mucosal immune system. The structure of IgA consists of two identical heavy chains and two identical light chains, linked by disulfide bonds. Human IgA exists as two subclasses, IgA1 and IgA2, that are structurally different in the flexible hinge region (1). The secreted form of IgA (SIgA) is the predominant mucosal antibody that contains two copies of IgA, a joining-chain (J chain), and a secretory component (SC) (2). IgA antibodies are expressed by B cells and are a part of both the innate and adaptive immune response (3). Since IgA antibodies are secreted by mucosa, they are important when studying autoimmune diseases associated with the gastrointestinal tract (4). Alternate Names constant region of heavy chain of IgA2; FLJ14473; FLJ35065; FLJ35500; FLJ36402; FLJ39698; FLJ40001; FLJ41548; FLJ41552; FLJ41789; FLJ43248; FLJ43594; FLJ44293; Ig alpha-1 chain C region; Ig alpha-1 chain C region BUR; Ig alpha-1 chain C region TRO; Ig alpha-2 chain C region; Ig alpha-2 chain C region BUT; Ig alpha-2 chain C region LAN; IgA1; IGHA1; IGHA2; immunoglobulin alpha 1; immunoglobulin alpha 2 (A2M marker); immunoglobulin heavy chain constant region alpha 1; Immunoglobulin heavy constant alpha 1; Immunoglobulin heavy constant alpha 2; immunoglobulin heavy constant alpha 2 (A2m marker); MGC102857 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Mouse IgG1