CST, 57583S, AdipoRon

Chemical Modulators for studying in the research area. Product Usage Information AdipoRon is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.17 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect. Storage Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles . Background AdipoRon is a small, synthetic molecule that binds both adiponectin receptors AdipoR1 and AdipoR2 with a Kd of approximately 1.8 and 3.1 mM, respectively. This synthetic adiponectin receptor agonist exhibits strong anti-obesity, anti-diabetic, anti-depressant, anti-ischemic, and anti-hypertrophic activities (1). AdipoRon behaves similarly to adiponectin in muscle and liver tissues of mice that are fed a high-fat diet, reducing insulin resistance and glucose intolerance through activation of the AMPK and PPAR-α pathways (2). Clinically, AdipoRon can be used to improve post-traumatic stress disorder, anxiety, and systemic sclerosis; it is being evaluated for the treatment of several forms of cancer, including pancreatic ductal adenocarcinoma, myeloma, breast, and ovarian cancer (3). Treatment of myeloma cell lines with AdipoRon significantly induced expression of the apoptosis-related proteins cleaved caspase-3 and cleaved PARP, and inhibited cell proliferation (4). A study using a mouse model of hypertension indicated that this AdipoRon treatment could prevent renal fibrosis in hypertensive patients (5). Alternate Names 2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide