Abcam, ab101207, Recombinant human PPIL4 protein

Size: 50µg / 250µg
Recombinant human PPIL4 protein is a Human Full Length protein, in the 1 to 512 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec, FuncS.
Key facts
Purity:>85% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:FuncS, SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Specific activity is > 190 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1 μmole of suc-AAPF-pNA per minute at 37°C in Tris-Hcl pH8.0 using chymotrypsin.,
Accession:Q8WUA2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PPIL4 also known as Peptidylprolyl Isomerase Like 4 is a member of the cyclophilin family of proteins. It exhibits peptidyl-prolyl cis-trans isomerase activity facilitating the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. The protein has a molecular weight of around 56 kDa and is ubiquitously expressed in various tissues throughout the body.
Biological function summary
PPIL4 participates in protein folding and assembly and it plays a role in maintaining cellular functions. This protein is part of complexes involved in RNA processing and mRNA splicing within the cell. It may interact with other spliceosomal components indicating its involvement in the regulation of gene expression through alternative splicing.
Pathways
PPIL4 is involved in the regulation of mRNA splicing influencing the expression of genes at the post-transcriptional level. It is connected to the spliceosome pathway where it associates with proteins like SNRNP200 and other spliceosomal proteins to modulate pre-mRNA splicing. This connection aids in the precise control of gene expression necessary for various cellular processes.
Altered PPIL4 function has implications in certain cancers and neurodegenerative diseases. Changes in PPIL4 expression may link to the disruption of normal splicing activities contributing to malignancies like adenocarcinomas. The protein's association with complex components like SNRNP200 could play a role in these diseases by affecting RNA processing stability and fidelity which are critical for maintaining normal cellular activities.