Abcam, ab101350, Anti-MIEF2 antibody

Size: 50µL
Rabbit Polyclonal MIEF2 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MIEF2 aa 250-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MIEF2 aa 250-450. The exact immunogen used to generate this antibody is proprietary information.Q96C03

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The mitochondrial elongation factor 2 (MIEF2) also known as SMCR7L plays a critical role in regulating mitochondrial dynamics particularly in the process of mitochondrial fusion. This protein with a molecular weight of approximately 48 kDa helps control the balance between mitochondrial fission and fusion which is essential for maintaining mitochondrial function and cellular homeostasis. MIEF2 is expressed in various tissues with pronounced expression in the heart brain and skeletal muscle reflecting its importance in high-energy-demand tissues.
Biological function summary
The regulation of mitochondrial dynamics through MIEF2 involves the modulation of mitofusin proteins which are integral to the fusion process. MIEF2 forms a part of large protein complexes that interact with mitofusin 2 (MFN2) to promote mitochondrial outer membrane fusion. This regulatory activity helps maintain the structural integrity of mitochondrian important for energy production and apoptosis regulation.
Pathways
MIEF2 plays a pivotal role within mitochondrial quality control pathways which are essential for cellular homeostasis. MIEF2's interaction with MFN2 is integral to the mitophagy pathway a specialized form of autophagy that removes damaged mitochondria. Additionally the coordination between MIEF2 and dynamin-related protein 1 (DRP1) has significant implications on the balance between fusion and fission processes therefore influencing the overall dynamics of mitochondrial networks.
MIEF2 shows connection to neurodegenerative diseases and cardiovascular disorders. Its role in mitochondrial dynamics makes it relevant in conditions such as Alzheimer's disease where mitochondrial dysfunction is observed. MIEF2's interaction with MFN2 is especially important in Charcot-Marie-Tooth disease type 2A a disorder affecting peripheral nerves. Understanding the dysregulation of MIEF2 can provide insights into the pathophysiology of these disorders highlighting its potential as a target for therapeutic intervention.