Abcam, ab101492, Anti-APP-1 antibody

Size: 100µL
Rabbit Polyclonal APP-1 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human PABPC4 aa 500-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PABPC4 aa 500-600. The exact immunogen used to generate this antibody is proprietary information.Q13310

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
APP-1 also known as Amyloid precursor protein 1 plays a significant mechanical role in cellular processes. It is a type I transmembrane glycoprotein with a molecular weight of around 110-130 kDa. APP-1 is widely expressed in various tissues but its highest levels are found in the central nervous system particularly within neurons. The processing of APP-1 occurs through cleavage by multiple secretases leading to the production of several fragments with different physiological roles.
Biological function summary
The alternative name Amyloid precursor protein reflects its pivotal involvement in neuronal growth and repair. APP-1 contributes to synaptic formation and plasticity being a part of a larger protein complex on the cell surface. Beyond its neuronal functions it plays roles in neural adhesion by interacting with extracellular matrix proteins. APP-1's fragments like amyloid-beta become relevant in cellular signaling and synaptic maintenance further influencing neuronal health.
Pathways
Research indicates that APP-1 is integral to the amyloidogenic and non-amyloidogenic pathways. It is connected to enzymes such as alpha beta and gamma secretases which modulate its cleavage and influence its downstream pathways. Interaction with proteins like presenilin is critical for processing APP-1 within the amyloidogenic pathway. These pathways collectively impact neurite outgrowth and neural development essential for maintaining cognitive functions.
Scientific studies have linked APP-1 to Alzheimer's disease due to the accumulation of its cleavage fragment amyloid-beta. This component aggregates to form plaques contributing to neurodegeneration and cognitive decline. Besides Alzheimer's variations in the APP-1 gene relate to cerebral amyloid angiopathy where deposition in blood vessels impairs circulation. Its interaction with Tau protein another key player in neurodegenerative diseases further associates APP-1 with the pathophysiology of these conditions.