Abcam, ab101710, Recombinant human TSSK1 protein

Size: 10µg
Recombinant human TSSK1 protein is a Human Full Length protein, in the 1 to 367 aa range, expressed in Baculovirus, with >80%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>80% SDS-PAGE,
Expression system:Baculovirus,
Tags:GST tag N-Terminus,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of TSSK1 was determined to be 60 nmol/min/mg.,
Accession:Q9BXA7,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.307% Glutathione, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00292% EDTA, 0.00174% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TSSK1 also known as Testis-Specific Serine Kinase 1 is a protein with a mass of approximately 36 kDa. This kinase is highly specialized and expressed mainly in the testes where it plays a role in male reproductive tissues. As a member of the serine/threonine kinase family TSSK1 transfers phosphate groups to serine residues on target proteins modulating their activity. This action is key for regulating various cellular processes especially in germ cells where it influences signaling pathways important for proper sperm development.
Biological function summary
TSSK1 contributes significantly to spermatogenesis and fertility. It forms part of a complex with other proteins to facilitate its role within the reproductive system. The protein modulates essential cellular processes such as cell division and differentiation during sperm cell maturation. Its activity supports the structural and functional integrity of the developing sperm essential for effective fertilization.
Pathways
TSSK1 activity integrates within signaling cascades related to reproductive functions. It participates in pathways like the protein phosphorylation pathway influencing partners such as TSSK2 and TSSK3 which share overlapping roles in spermatogenesis. Such interactions highlight the focus of TSSK1 in coordinating processes that ensure proper sperm function and associated developmental pathways.
TSSK1 links to conditions affecting male fertility including non-obstructive azoospermia and oligozoospermia. Disruption in TSSK1 function can lead to faulty sperm production contributing to infertility. Through its involvement in these conditions TSSK1 may also interact with proteins like YBX3 which holds roles in RNA regulation during spermatogenesis further underpinning the complex network of processes integral to reproductive health.