Abcam, ab101851, Anti-PROX1 antibody - BSA and Azide free

Size: 100µg
Anti-PROX1 antibody - BSA and Azide free (ab101851) is a rabbit polyclonal antibody provided in a PBS only buffer for easy conjugation detecting PROX1 in IHC-Fr . Suitable for Mouse . - BSA, sodium azide, and glycerol-free for easy conjugation - Over 30 publications - Trusted since 2010
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse,
Applications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PROX1 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92786

Product details:
What is this antibody validated in?
Anti-PROX1 antibody - BSA and Azide free (ab101851) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-Fr) in Mouse samples.
Trusted by the scientific community
Anti-PROX1 - BSA and Azide free (ab101851) was first used in a scientific publication in 2010 and has been cited over 30 times in peer-reviewed journals.
Reviewed by scientists
Anti-PROX1 - BSA and Azide free (ab101851) has over 5 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PROX1 protein also known as Prospero homeobox 1 acts mechanically as a transcription factor and plays an important role in cell differentiation. Its molecular mass is about 83 kilodaltons. This protein is expressed in a range of tissues including the liver heart and lymphatic system. During embryonic development PROX1 is notably active where it participates in organogenesis and differentiation into specific cell types.
Biological function summary
PROX1 influences numerous processes by regulating gene expression. It forms part of several protein complexes that determine the fate of lymphatic endothelial cells balancing between lymphatic and blood vascular destinies. PROX1 directly affects the promotion and maintenance of the lymphatic endothelial cell phenotype. Its activity is fundamental to the development and maintenance of several organs and tissues impacting overall physiological function.
Pathways
The transcription factor PROX1 integrates into the VEGF signaling pathway and the Wnt signaling pathway. Within these pathways it interacts closely with other proteins such as VEGF-C and Β-catenin. PROX1 modulates these pathways to orchestrate cell proliferation migration and vessel formation. Through its interactions PROX1 significantly contributes to the intricate communication between cells in developing tissues.
Research indicates that dysregulation of PROX1 is linked to cancer and lymphatic diseases. In cancer particularly colorectal and breast cancers aberrant PROX1 expression can promote tumor progression. It interacts with proteins like NF-κB which influence inflammatory responses and cell survival. Similarly in lymphedema altered PROX1 can disrupt normal lymphatic development affecting fluid balance and immune function in the body.