Abcam, ab101984, Anti-Ancient ubiquitous protein 1 antibody

Size: 100µg
Rabbit Polyclonal Ancient ubiquitous protein 1 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human AUP1 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human AUP1 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y679

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ancient ubiquitous protein 1 also known as AUP1 is a multifunctional protein with a mass of approximately 43 kDa. It plays an important role mechanically in the regulation of lipid droplet dynamics and protein degradation. AUP1 is ubiquitously expressed across various tissues with high levels observed in the liver and adipose tissue. It has been linked to cellular processes that manage protein quality control via ubiquitin-proteasome system.
Biological function summary
The Ancient ubiquitous protein 1 contributes to maintaining cellular homeostasis through its involvement in lipid metabolism and endoplasmic reticulum (ER) stress response. It acts as part of protein complexes that modulate ubiquitination activity influencing the fate of damaged or misfolded proteins. AUP1 interacts with various cellular machinery to stabilize lipid droplets impacting energy storage and usage. By engaging with these complexes it safeguards cells under stress conditions supporting proper cellular function.
Pathways
Ancient ubiquitous protein 1 influences both the ubiquitin-proteasome pathway and ER-associated degradation pathway. It collaborates with ubiquitin-related proteins like ubiquitin-conjugating enzyme UBE2G2 to enhance protein turnover maintaining protein homeostasis and stress resilience. By participating in these pathways AUP1 enables proper protein folding and disposal which are essential for cellular adaptation and response to metabolic demands and stress signals.
Ancient ubiquitous protein 1 has associations with metabolic disorders and neurodegenerative diseases. Dysregulation of AUP1 can lead to liver disease and type 2 diabetes due to its role in lipid storage and ER stress. Additionally AUP1 interactions with proteins like sequestosome 1 link it to neurodegenerative conditions where disrupted protein degradation and cellular stress responses contribute to disease progression. Understanding its function in these contexts can illuminate therapeutic approaches for these complex disorders.